First map of proinsulin’s ‘social network’ reveals new drug target for type 2 diabetes

Scientists at Sanford Burnham Prebys Medical Discovery Institute have mapped for the first time the vast network of proteins that interact with proinsulin, the protein the body normally processes into insulin. The study, published in Diabetes, also revealed one protein—called PRDX4—that may be essential for proinsulin folding and insulin production. The research suggests that boosting […]

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Exxon shareholders soundly reject splitting CEO/chairman roles

Exxon Mobil Corp (XOM.N) shareholders soundly rejected climate-related proposals and splitting the chairman and chief executive’s roles at the oil major’s shareholder meeting on Wednesday. Climate activists had swung behind efforts to split the roles of chief executive and chairman after prior defeats on resolutions seeking to make it more accountable to shareholders on climate […]

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